Sildenafil Review for Persistent Erection and Widening of Blood Vessels

Sildenafil – the most bought drug for excitement around the world. Sildenafil effectively combats erectile dysfunction in men and maintains a penis hardness sufficient for sexual intercourse. It has a beneficial effect on blood circulation in the pelvic region, which contributes to the expansion of blood vessels.

It provides excellent results even in serious pathologies such as spinal cord injuries, prostate surgery, diabetes and other diseases that negatively affect sexual function. Wide popularity and sales statistics in pharmacies confirm the high effectiveness of the drug in eliminating sexual problems.

Since 1977, American pharmacologists have been working on the development of a substance that could narrow and expand the blood vessels in the heart, brain and lungs. This lasted until 1992, the year scientists began testing Sildenafil Citrate. Until then, however, there were no noticeable results from their work. The tests were conducted with the aim of creating a drug for the treatment of diseases of the cardiovascular system.

Sildenafil citrate exhibited an unexpected property of blocking certain enzymes. This led to a widening of the blood vessels in the area of ​​the genitourinary system. The substance caused a persistent and long-lasting erection, which pleasantly surprised the men who took part in the tests.

Then the substance was examined in a different direction. As a result, all known Viagra tablets appeared in 1998. In the same year sildenafil received three scientists the Nobel Prize for the creation of a medication for the treatment of heart and lung disease. The makers of Viagra had developed a drug with Sildenafil that would prove to be groundbreaking.

Indications and composition

Sildenafil is released in the form of citrate. Shelf life is 2 years.

The main form of release – tablets, continuously dose the active ingredient in 25mg, 50mg or 100mg. In classic Viagra, the tablets have a diamond-shaped, convex shape and the pills are covered with a recognizable blue coating. Equals of the drug, of which a wide range is available, are produced not only in tablets, but also in the form of powder, capsules (100 mg) and drops. In one package Sildenafil can contain 1 to 12 tablets.

In addition to the basic substance, the preparation contains such auxiliary components as povilone, cellulose, magnesium stearate, lactose monohydrate and some other ingredients.

Mechanism of the Action

Sildenafil is classified as a selective inhibitor of PDE-5 (type 5 phosphodiesterase). The principle of its action is based on the widening of blood vessels in the genitals and the increase in blood flow to the penis.

This makes it possible for men to get a good and long erection. Buying sildenafil can eliminate problems with erectile function manifested by the inability of the penis to maintain the necessary hardness for sexual contact. This effect of the drug is due to its ability to affect the enzymes responsible for achieving penile erection.

However, as mentioned before, tablets cannot stimulate an erection on their own, if there is no sexual attraction to the partner. If there is a natural desire, the excitement increases and Sildenafil will be able to support this excellently.

The drug restores the lost response to sexual arousal. Normal erections are impossible without the release of nitric oxide in the erectile tissues of the penis, which activate the enzyme guanylate cyclase. Its activation involves an increase in the level of the specific nucleotide – cyclic guanosine monophosphate (cGMP), which is necessary to relax the muscles of the cavernous body, resulting in increased blood flow in the penis.

Indications for the use of the drug are not only erectile dysfunction, but also pulmonary hypertension. The drug expands the vessels in the respiratory organs and reduces the pressure in them. Thanks to this remedy, respiratory problems in people with this disease are significantly reduced, and shortness of breath is also reduced.

In addition, the ability of the drug to reduce pressure has been proven. However, this effect only lasts during the action of the tablets and after completion the pressure is restored to the previous values.

Indications and Features

The drug Sildenafil should preferably be taken one hour before intimacy. Do not be afraid that the drug will act prematurely, because the effect of its use in men comes on only with natural sexual arousal.

If there is no desire for a partner then – as it should be – no erection will occur. If you have to choose between doses of 25mg, 50mg or 100mg, you should consult a specialist who will prescribe the required concentration of the substance based on the individual characteristics of the patient.

As a general rule, 25-50 mg will be sufficient as a starting dose. Instructions for use of the drug contain instructions on the maximum daily dose, which should not exceed 100mg. It is not recommended to take the maximum amount the first time. It is recommended to rinse the tablets with a large amount of water, as they have a specific taste.

The duration of the remedy is 5 hours, effective duration of action is between 4-6 hours. The effect of taking medication remains in men throughout sexual contact and it supports the natural ability to perform sexual intercourse healthy and energetically. In case of repeated desire for intimacy before the appearance of an erection, no additional use of the drug is necessary.

Tablets can be consumed on a full or empty stomach, but it should be taken into account that the absorption of this drug will take 20-25 minutes longer after consuming fatty foods. Viagra and its generic variants (Sildenafil Medan, Maxigra, etc.) can be combined with moderate dose of alcohol.

Pulmonary hypertension Indication

It is not convenient to use 100mg tablets for this application as the recommended dose is usually 25mg 3 times a day – at 7-8 hour intervals. There are tablets with smaller doses that are better suited for this.

If someone tolerates the drug well, the dose can be increased to 50mg at a time. however, it is not necessary or advisable to use more than 100mg per day without a doctor’s instructions.

Older people should take this medicine at a dose of only 25 mg at a time. The same goes for men and women who suffer from kidney and liver diseases. If the drug is poorly tolerated by the body, a daily dose of 100mg is not recommended. 50mg per day is more sensible, divided into 2 doses of 25mg.

Sildenafil for women

Recently, Viagra and its analogues can be used more and more to eliminate intimate problems not only for men, but also for the fair sex. Their effectiveness in women has been proven even at menopause and after removal of the uterus.

Due to the use of drugs, such effects were found in the fair sex:

  • increased libido;
  • sensuality enhancement;
  • reduction of the time during which arousal occurs;
  • increased vaginal moisture;
  • improving blood circulation in the genital area;
  • increased sensitivity in erogenous zones;
  • increased duration of orgasm;
  • elimination of frigidity;
  • increased sexual desire in older women;
  • increased stamina with intimacy.

Tablets have a complex effect on women, because in addition to intensifying arousal, they stimulate sexual attraction to the sexual partner. Increased blood flow in the pelvic organs contributes to greater sensitivity and clarity of feelings during intimacy. Thanks to this preparation, the vagina is naturally much better moistened, therefore its use is recommended in case of vaginal dryness.

 

Contra Indications

Before taking Sildenafil, you should consult a specialist because the instructions for use of the medication contain many contraindications, which are dangerous to ignore. There are a number of diseases against which Viagra and similar drugs are prohibited. Among them the following pathologies:

  • angina pectoris
  • Liver disease in severe form
  • Stenosis of the aorta
  • cardiomyopathy
  • Hypotension
  • Heart failure
  • Heart attack or stroke
  • Some retinal pathologies
  • Age up to 18 years
  • Individual intolerance of the drug and allergy to its components

In addition to the diseases described above, there are relative contraindications to taking medication. In the following pathologies, admission can be allowed only with the permission of a doctor. These include:

  • Leukemia
  • Anomalies in the structure and deformation of the penis
  • Anemia sickle cell type
  • myeloma
  • Low level of platelets in the blood
  • Diseases in which blood loss can occur (for example, an ulcer in an acute form)

In order to use the drug effectively without the occurrence of negative consequences, the possible side effects and disadvantages should be considered very carefully.

Ventricular Extrasystole and Medication Use

For people who have had problems with heart problems, its use carries an increased risk and should only be used under supervision. Ventricular extrasystole is another pathology where using Sildenafil can be dangerous. It is a disease associated with cardiac arrhythmias and the appearance of additional impulses in the heart. Pathology is accompanied by the following symptoms:

  • Unusual sensations in the region of the heart (for example, loud unstable strokes)
  • Dizziness
  • shortness of breath
  • Feeling of fear, fear

There are signs of lung disease similar to hypertension, where sildenafil appears. Possibly accompanied by shortness of breath and hypertension. However, before using the medicine to treat this symptom, you must be diagnosed and treated by a specialist. This will be able to easily determine the cause of the unpleasant symptoms.

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