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Nonoxynol-9 is used for local contraception used as a gel or in the form of foam suppositories.

Main Uses

  • Prevent conception
  • Inactivate sperm

Mode of Action

Nonoxynol 9 kills sperm by destroying its cell wall, thus preventing the fertilization of the egg during sexual intercourse. In addition, the active ingredient also inactivates bacteria (such as chlamydia ), fungi (such as yeasts) or the herpes simplex virus . 
This special mode of action is not used therapeutically.

Side Effects

These side effects may not occur as every person reacts differently to medication. Please also note that the type and frequency of adverse reactions may vary depending on the drug formulation (eg tablet, syringe, ointment).

Rare side effects: 
feeling warm, local irritations such as burning or itching (also possible with the sexual partner).

Special Side effects: 
The active ingredient can – especially when used regularly – irritate and injure the vaginal mucosa. This increases the risk of becoming infected with the HIV virus during intercourse. The use must be stopped if the user or her partner shows signs of irritation to the vagina or penis.

Warnings & Precautions

  • The tensile strength of latex products such as condoms may be compromised.
  • The drug does not protect against infections with the HI virus or other sexually transmitted diseases.

Sometimes medicinal substances trigger allergic reactions. If you notice any signs of allergic reaction, tell your doctor or pharmacist immediately.


Below you will find information on contraindications to the use of Nonoxynol 9 in general, during pregnancy and lactation, and in children. Please note that the contraindications may vary depending on the drug formulation of a drug (for example, tablet, syringe, ointment).

When should Nonoxynol 9 not be used?

Nonoxynol 9 must not be used in case of hypersensitivity to the active substance.

Products containing nonoxinol 9 may only be used in the vagina but not in the rectum.

What should I watch for pregnancy and breastfeeding?

The area of ​​application excludes treatment with the active ingredient during pregnancy .

What should be considered in children?

The indication excludes treatment of children with nonoxynol 9.

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