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Exforge HCT

Exforge HCT – Best Triple Therapy For Severe Hypertension

Exforge HCT is an antihypertensive medicine contains three active substances: Amlodipine, a so-called calcium antagonist, Valsartan, a so-called angiotensin II receptor antagonist, and Hydrochlorothiazide (HCT), a water-exhaling substance (diuretic). These three substances reduce blood pressure in different ways.

If the high blood pressure persists for an extended period of time, it can cause damage to the brain, heart and kidney vessels and ultimately lead to a stroke, heart attack or kidney failure. Reducing your blood pressure to a normal level reduces the risk of these illnesses. Exforge HCT is manufactured by Novartis Pharma.

Main Uses

Exforge HCT is used to treat high blood pressure:

  • in patients in whom the blood pressure can not be lowered sufficiently by treatment with two active substances,
  • in patients already receiving the three active substances amlodipine, valsartan and hydrochlorothiazide, but as separate tablets.

Exforge HCT should only be used on prescription of the doctor.

Dosage Guide

The recommended dose of Exforge HCT is one tablet per day, preferably in the morning. It is advisable to take the medicine at the same time every day.

Exforge HCT can be given to older patients (65 years and older) at the same dosage as other adults.

If you ever forget to take Exforge HCT, get it as soon as possible and then take your next tablet at the usual time. If it is already time for your next dose, skip the missed dose. Do not take a double dose. If you accidentally take too many tablets, tell your doctor immediately.

How to Take ?

Exforge HCT can be taken with or without food. Swallow the film-coated tablet with a glass of water. Ending treatment with Exforge HCT can make your condition worse. Do not stop taking it until your doctor has told you.

Precautions

  • This medicine may interfere with responsiveness, fitness to drive, and the ability to operate machinery or tools due to potential side effects such as dizziness or tiredness.
  • Caution is advised if you have kidney, gallbladder or liver disease or if you have allergies or asthma.
  • Before beginning treatment with Exforge HCT, your doctor will control your circulation and your blood, and if there is any lack of fluids and salts, balance them first to avoid over-lowering your blood pressure.
  • Even during therapy with Exforge HCT, it will control the salts (especially potassium, sodium, magnesium, calcium) in the blood because Exforge HCT can alter the salt concentration in the blood. He or she may also check your kidney function.
  • If you have taken a so-called beta-blocker and can now sell this, this should be done slowly; Your doctor will give you instructions.
  • If you have a kidney transplant, the doctor will not use Exforge HCT with you as a precautionary measure.
  • Caution should be exercised when taking an ACE inhibitor or aliskiren (high blood pressure medicines).
  • If you suffer from valvular heart disease, myocardial disease, certain kidney disease (renal artery stenosis), or lupus erythematosus (immune system with skin involvement), the doctor will specifically monitor you while you are taking Exforge HCT.
  • If you experience reactions such as swelling of the face, arms and legs, eyes, lips or tongue (signs of angioedema) after taking Exforge HCT (or other medicines such as ACE inhibitors), stop using Exforge HCT immediately and contact your doctor immediately.
  • If you have heart failure or a heart attack. Carefully follow your doctor’s instructions for the initial dose. Your doctor may also check your kidney function.
  • After starting treatment, you may experience worse chest pain (angina pectoris) or heart attack.
  • Using Exforge HCT may cause an increase in blood sugar (with the possibility of the onset or worsening of diabetes), cholesterol and other fats in the blood, and uric acid in the blood (which may trigger a gout). The doctor will therefore check you regularly for these problems and take appropriate measures if necessary.
  • If you experience a sudden decrease in vision or eye pain, these may be symptoms of increased pressure in your eyes. These can occur within hours to weeks after the start of treatment. In this case, please contact your doctor immediately.

Side Effects

The following side effects may occur when taking Exforge HCT:

Frequently:

Dizziness, headache, low blood pressure (with symptoms such as dizziness or dizziness), indigestion, frequent urination or increased urination, fatigue, fluid retention in the tissues with swelling of the face, arms, hands, legs, ankles or feet.

Occasionally:

Loss of appetite, insomnia, lack of coordination, dizziness on getting up, dizziness after exertion, taste disorder, lethargy, nervous system disorders with signs such as tingling or numbness of hands or feet, nerve pain, paralysis and weak muscle reflex, drowsiness, fainting, blurred vision, vertigo, accelerated pulse, Rising blood pressure, superficial phlebitis, acute thrombosis, coughing, difficulty in breathing, sore throat, abdominal discomfort, upper abdominal pain, bad breath, diarrhea, dry mouth, nausea, vomiting, increased sweating, itching, back pain, joint swelling, muscle spasms, muscle weakness, muscle pain, pain in the arms or legs, acute kidney failure, erectile dysfunction, inability to walk, gait disorder, weakness, discomfort,Malaise, chest pain, weight gain.

Furthermore, shifts in the electrolytes (salts) in the blood and an increase in fats and uric acid in the blood can occur.

Possible additional undesirable effects with amlodipine, valsartan or hydrochlorothiazide alone:

amlodipine

Undesirable effects which can be serious:

Spontaneous bleeding or small bleeding (possible signs of thrombocytopenia), fever, sore throat or mouth due to infection (signs of leucocytopenia), irregular heartbeat (possible signs of atrial fibrillation), slow heartbeat (possible signs of bradycardia), sudden and distressing chest pain (possible signs of bruising) Heart attack), severe upper abdominal pain (possible signs of pancreatitis), yellow skin and eyes, nausea, loss of appetite, slightly discolored urine (possible signs of hepatitis), blisters on the lips, eyes or mouth, skin peeling, fever (possible signs of erythema multiforme or Steven-Johnson syndrome).

Frequently:

Palpitations, flushes

Occasionally:

Mood swings, tremor, reduced skin sensitivity (hypoaesthesia), diplopia, tinnitus, runny nose, altered bowel habits, alopecia, erythema, skin discolouration, photophobia, joint pain, urinary disorders, increased nocturnal urination, male breast enlargement, pain, weight loss.

Very rare:

Hypersensitivity, increased blood sugar, increased blood pressure, cardiac arrhythmia, inflammation of the blood vessels, gastric inflammation, gingival thickening, inflammation of the pancreas or liver inflammation (both can lead to symptoms such as vomiting, loss of appetite, nausea or yellow discoloration of the skin and eyes), angioedema (respiratory and respiratory reaction) Dysphagia, swelling of the face, arms and legs, eyes, lips or tongue), dermatitis, urticaria.

valsartan

Undesirable effects, which can be serious:

Symptoms of an allergic reaction or edema (rash with or without difficulty in breathing, reaction to respiratory and swallowing symptoms, swelling of the face, arms and legs, eyes, lips or tongue)

Frequently:

Viral infections

Occasionally:

Heart failure, blistering on the skin Respiratory tract infections, pharyngitis, inflammation of the sinuses, reduced white blood cell count, which may increase the risk of infection, increased potassium blood levels, decreased libido

Very rare:

Renal impairment, complications during pregnancy

hydrochlorothiazide

Undesirable effects, which can be serious:

Skin rash, especially on the face, joint pain, muscle symptoms and fever (sign or reactivation of lupus erythematosus). Serious skin reactions with blistering on the lips, eyes or in the mouth, peeling of the skin, fever (toxic epidermal necrolysis).

Frequently:

Low magnesium levels in the blood

Rare:

Increased blood sugar, sugar in the urine, worsening of diabetes, photophobia reactions, constipation, depression, low vision

Very rare:

Difficulty in breathing, including pneumonia, pulmonary edema, inflammation of the pancreas

Muscle cramps, fever, weakness (asthenia), poor eyesight or pain in the eyes (high eye pressure), severely reduced urine volume (kidney disease or kidney failure) have also been reported.

Contraindications

There are some conditions where it’s not recommended to take Exforge HCT, If any of these apply to you, tell your doctor before taking Exforge HCT.

  • If you have ever had an unusual or allergic reaction to amlodipine, valsartan or hydrochlorothiazide or sulfonamides or any other ingredient in this medicine. If you think you may be allergic, ask your doctor for advice.
  • If you are pregnant or planning to become pregnant or breastfeeding.
  • If you suffer from gallbladder congestion. If you suffer from a greatly reduced amount of urine (anuria).
  • If you have type 1 or type 2 diabetes or impaired kidney function while taking the antihypertensive drug aliskiren.
  • In the event of swelling of the face, lips, tongue or throat (difficulty in swallowing or breathing) when taking an antihypertensive drug.

Children & Adolescents

The use of Exforge HCT in children and adolescents under the age of 18 years is not recommended.

Pregnancy & Breastfeeding

You should not take Exforge HCT if you are pregnant or planning to become pregnant. The use of Exforge HCT in pregnancy has been associated with serious harm to the unborn child. Therefore, it is important to consult your doctor if you think you may be pregnant or are planning to become pregnant.

If you are breastfeeding, tell your doctor about lactation. During treatment with Exforge HCT must not be breastfed.

Drug Interactions

Use of Exforge HCT with other medicines or food may interact (increase or decrease the effect of Exforge HCT or the other medicine or increase side effects).  These include: Potassium-containing medicines, potassium-containing salt substitutes, and other medicines that can increase blood potassium (eg, heparin to dilute the blood.) Your doctor may periodically check the potassium level in your blood.

Water-expelling medicines, certain medicines for the treatment of infections (amphotericin B, penicillin G), other anti-hypertensive medicines, in particular ACE inhibitors or aliskiren, lithium (a medicine for the treatment of certain mental disorders), antidepressants, antipsychotics (for the treatment of certain psychiatric disorders), medicines against epilepsy (such as carbamazepine), anti-inflammatory and analgesics (so-called non-steroidal anti-inflammatory drugs including COX-2 inhibitors), cortisone drugs (steroids), antiarrhythmics (for the treatment of cardiac arrhythmias), digoxin or other digitalis glycosides (cardiac), muscle relaxants ( for muscle relaxation during surgery), allopurinol (gout), amantadine (for the treatment of Parkinson’s disease, also in certain viral diseases),certain anticancer drugs, anticholinergic agents (for the treatment of various disorders such as gastrointestinal spasms, bladder spasms, asthma, motion sickness, muscle spasms, Parkinson’s disease and as an aesthetic), ciclosporin (for the prevention of organ rejection after transplantation) other diseases such as rheumatoid arthritis or atopic dermatitis), insulin or oral antidiabetic medicines, colestyramine, colestipol and other resins (for the treatment of high blood lipids), vitamin D and calcium salts, hypertensive amines (such as norepinephrine), barbiturates (sedatives), narcotics (sedatives ) and alcohol.Parkinson’s disease and as an aid to anesthesia), cyclosporine (for the prevention of organ rejection after transplantation or in other diseases such as rheumatoid arthritis or atopic dermatitis), insulin or oral antidiabetic medicines, colestyramine, colestipol and other resins (for the treatment of high blood lipids), vitamin D and calcium salts, antihypertensive amines (such as norepinephrine), barbiturates (tranquilizers), narcotics (sleep aids) and alcohol.Parkinson’s disease and as an aid to anesthesia), cyclosporine (for the prevention of organ rejection after transplantation or in other diseases such as rheumatoid arthritis or atopic dermatitis), insulin or oral antidiabetic medicines, colestyramine, colestipol and other resins (for the treatment of high blood lipids), vitamin D and calcium salts, antihypertensive amines (such as norepinephrine), barbiturates (tranquilizers), narcotics (sleep aids) and alcohol.hypertensive amines (such as norepinephrine), barbiturates (sedatives), narcotics (sedatives) and alcohol.hypertensive amines (such as norepinephrine), barbiturates (sedatives), narcotics (sedatives) and alcohol.

Tell your doctor or pharmacist if you are currently (or recently) taking any other medicines that alter the amount of amlodipine in your body, especially medicines for fungal infections (such as ketoconazole, itraconazole), for the treatment of AIDS or HIV Infections (such as ritonavir, indinavir),

Also Simvastatin (medicines to control elevated cholesterol) and diltiazem (for heart disease).

Tell your doctor or pharmacist if you are currently (or recently) taking any other medicines that alter the amount of valsartan in your body, in particular certain antibiotics (rifamycin group), medicines used to protect against transplant rejection, or antiretroviral drug for the treatment of HIV / AIDS (ritonavir). These medicines can increase the effects of valsartan.

Grapefruit juice should not be taken in large quantities (more than ½ liter per day) during treatment with Exforge HCT.

Package

  • Exforge HCT 5 mg / 160 mg / 12.5 mg tablets contain amlodipine 5 mg, valsartan 160 mg and hydrochlorothiazide 12.5 mg as well as excipients.
  • Exforge HCT 10 mg / 160 mg / 12.5 mg tablets contain amlodipine 10 mg, valsartan 160 mg and hydrochlorothiazide 12.5 mg as well as excipients.
  • Exforge HCT 5 mg / 160 mg / 25 mg tablets contain amlodipine 5 mg, valsartan 160 mg and hydrochlorothiazide 25 mg as well as excipients.
  • Exforge HCT 10 mg / 160 mg / 25 mg film -coated tablets contain amlodipine 10 mg, valsartan 160 mg and hydrochlorothiazide 25 mg as well as excipients.

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SuperB

Exforge HCT is one of the best treatments for severe hypertensive patients. By decreasing the number of pills that the patient has to take, Exforge HCT has increased the control rates and complaince

User Rating: 5 ( 1 votes)
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