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coralan 5mg , coralan 7.5mg

Coralan – for Chronic Angina Patients Who Cannot Take Beta Blockers

Coralan, another brand of Procoralan, is used to treat chronic heart failure and the symptoms of chronic angina in adults who can not take beta blockers. The drug may also be used in combination with beta-blockers in patients whose optimal beta-block dose is insufficient. Coralan tablets contain 5mg and 7.5mg of Ivabradine.

Medicinal Uses

  • in patients intolerant or resistant to beta blockers.
  • in combination with beta blockers in patients not adequately controlled with beta-blockers and having a heart rate> 60 beats / min.


How is Coralan administered to adults?

The recommended starting dose is 5 mg Coralan twice daily. After 3-4 weeks of treatment, the dose may be increased to 7.5 mg twice daily, depending on the response.

If during a course of treatment the heart rate drops below 50 times per minute at rest, persistent or delayed bradycardia, such as dizziness, fatigue or hypotension, The dose must be reduced to 2.5 mg twice a day (half of 5 mg twice a day).

Treatment should be stopped if the heart rate is less than 50 beats per minute or the symptoms of temporary bradycardia persist.

Elderly have only been studied in a limited number of patients ≥75 years of age. Consideration should be given to lowering the initial dosage for these patients (Coralan 2.5 mg twice daily). or half a pill of 5 mg  twice daily before dosing, if necessary.

Renal failure : No Coralan dose adjustment is required in patients with renal impairment and creatinine clearance> 15 ml / min. There are no data in patients with creatinine clearance less than 15 ml / min. Coralan is therefore used with caution.

Liver failure : No dose adjustment is needed for patients with mild hepatic impairment. Coralan should be used with caution in patients with moderate hepatic impairment. Coralan drug is contraindicated in patients with severe hepatic impairment, as there is no research available for these patients

How is Coralan administered to children?

Dosage for children has not been studied. Ask your doctor if you plan to use this medicine for your baby.

How to Take Coralan?

You should take Coralan tablets twice a day with food (morning and evening meals). In particular, do not use Coralan in low doses, high or longer than the specified time.

You can take with or without food. However, you can take Coralan with food to reduce stomach upset. Besides, you need to take the whole pill with a full glass of water.

Forgotten Dose

If you forget to take a dose, use as soon as possible. However, if you are close to the next dose, skip the missed dose and take the next dose at the scheduled time. Do not double the prescribed dose to compensate for forgotten dose

In an emergency or overdose, call the nearest emergency center or go to the nearest local health unit. In addition, you should record and bring along the list of medications you take, including prescription and over-the-counter medications.

Side Effects

Clinical trials were performed on nearly 5,000 participants. About 2,900 patients were treated with Coralan in Phase II-III studies. Most of the undesirable effects associated with Coralan are dose dependent and are related to the pharmacological effects of the drug.

Coralan can cause some side effects such as:

  • Visual disturbance;
  • Blurred vision;
  • Slow heart rate;
  • Congestive heart failure level 1;
  • Headache (usually in the first month of treatment);
  • Dizziness ;
  • Uncontrolled blood pressure;
  • Fainting;
  • Feeling weak or tired;
  • Lowering blood pressure ;
  • Palpitations;
  • Extra heart failure;
  • Irregular heartbeat;
  • Shortness of breath;
  • Dizziness;
  • Intestinal disorders ( nausea , constipation , diarrhea , abdominal pain );
  • Rash;
  • Angina ;
  • Cramps ;
  • Leukocytosis;
  • Increased serum creatinine levels;
  • Increased uric acid in the blood ;
  • Vision problems;
  • Heart block level 2 or 3, sinus node syndrome or atrial fibrillation .

This is not a complete list of all side effects and may have other side effects. If you have any questions about side effects, consult your doctor or pharmacist.

Caution / Warning

Before taking the medicine, you should tell your doctor or pharmacist if:

  • You are pregnant or breastfeeding. You need to take the medicine prescribed by your doctor in this case;
  • You are allergic to any of the ingredients of Coralan;
  • You are taking other medicines (including over-the-counter, prescription, herbal and functional supplements);
  • You intend to use drugs for children or the elderly;
  • You are or have had any medical condition such as heart failure, unstable angina, heart rate slower than 70 beats per minute before treatment, acute myocardial infarction , cardiac shock, sinus, atrioventricular blockage, cardiac arrest level 2 or 3, hypotension, galactose intolerance, lactase deficiency or glucose-galactose malabsorption, arrhythmias and decreased liver function. You should also let your doctor know if you have an artificial pacemaker.

Pregnancy & lactation

There are no adequate studies to determine the risk of Coralan during pregnancy or lactation. Before taking any medicine, always consult your doctor to weigh the benefits and risks.

Drug interactions

Coralan can alter the ability of other drugs you are taking or increase the effect of side effects. To avoid drug interactions, it’s a good idea to write a list of what you are taking (including prescription and over-the-counter medicines, herbs and functional foods) and see your doctor or pharmacist. To ensure the safety of your medication, do not take medication, discontinue or change the dose of medication without your doctor’s permission.

Medications that may interact with Coralan include:

  • Antiarrhythmic drugs;
  • Antidepressants ;
  • Antimalarial drugs ;
  • Certain antibiotics, such as erythromycin , clarithromycin , moxifloxacin or pentamidine;
  • Certain antipsychotic medications, such as pimozide , sertindole, thioridazine , haloperidol;
  • Cisapride ;
  • Methadone ;
  • Ranolazine ;
  • Tolterodine ;
  • Vardenafil ;
  • Antifungal agents of the azole group;
  • Macrolide antibiotics ;
  • Nefazodone ;
  • Protease inhibitors HIV;
  • Diltiazem and verapamil ;
  • Sedative;
  • Phenytoin ;
  • Rifampicin.

Food Interactions

You should use caution when taking Coralan with grapefruit or grapefruit juice. Food, alcohol, and tobacco can interact with certain drugs. Check with your doctor about taking the same medicine, food, alcohol and cigarettes.

Diseases Interactions

Your health status may affect the Coralan use. Tell your doctor if you have any health problems, especially:

  • Decreased liver function;
  • Severe renal function (creatinine clearance less than 15 ml / min);
  • Lowering blood pressure;
  • Severe heart failure;
  • Irregular heartbeat;
  • Retinitis pigmentation .

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User Rating: 4.7 ( 1 votes)

One Unbiased Opinion

  1. Anonymous

    My Doctor has prescribed me this drug some months ago and it works great for me.

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