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Aarane N

Aarane N is available in the form of a metered dose inhaler. The active ingredient combination reproterol and cromolyn sodium is used for the prevention and treatment of respiratory diseases such as bronchial asthma, COPD (chronic obstructive pulmonary disease) and chronic bronchitis . Long-term treatment also requires anti-inflammatory therapy (such as glucocorticoids ).


Aarane N contains the active ingredients cromoglicic acid and reproterol

The following non-active ingredients are included in the drug:

  • Dentomint PH / 799959 Haarmann & Reimer (Aroma)
  • Ethanol 96%
  • Poly (oxyethylene) -25-glycerol trioleate


Bronchial dilation in addition to the basic anti-inflammatory therapy for the prevention and treatment of respiratory distress in bronchial asthma


For long-term treatment, adults and children initially inhale two sprays four times a day. If there are no more complaints, the dosage can be gradually reduced as long as no symptoms occur, following medical advice.

To specifically prevent an asthma attack, two sprays must be taken 10 to 15 minutes before allergen contact or before exertion.

In case of acute respiratory distress, an additional spray should be inhaled. If no improvement occurs after five minutes, another spray can be inhaled. In the event that a severe respiratory distress syndrome does not improve significantly even after a second spray, further inhalations can be made. At the same time immediate medical help is required.

The maximum daily dose should not exceed 16 sprays.

Side Effects

Uncommon side effects: 
headache , muscle tremors ( tremors , such as the fingers and hands), palpitations ( palpitations ), restlessness, skin inflammation, muscle inflammation, inflammation in the gastrointestinal tract, irritation of the bronchial tubes (such as nausea, cough)

Rare side effects: 
mouth irritations, throat irritations, hypersensitivity reactions ( hives , skin rash)

Very rare side effects: 
allergic pneumonia , muscle aches, joint pain, dizziness, hoarseness, hemoptysis, angina pectoris , heart beats ( extrasystoles ), heartburn, kidney damage, painful urination, peripheral nerve inflammation, pericarditis, artery inflammation, fluid retention ( edema ), laryngeal swelling, facial swelling , punctate skin bleeding ( purpura ), bronchoconstriction, reduction of platelets ( thrombocytopenia ), allergic shock ( anaphylactic shock ), psychosis

Side effects without frequency: 
decrease of potassium concentration in the blood ( hypokalemia ), increase in blood sugar levels, acceleration of the heartbeat ( tachycardia )

Drug Interactions

The concomitant use of reproterol and cromoglycic acid with bronchodilators such as muscarinic receptor antagonists or theophylline leads to a mutual enhancement of action. This also increases the unwanted side effects on the heartbeat, such as cardiac arrhythmia or an increase in heart rate.

Beta-blockers weaken the effects of reproterol and can cause severe constriction of the bronchi .

If oral antidiabetics are used in conjunction with reproterol , their hypoglycemic effect may be reduced. The dose may need to be readjusted.

Halogenated hydrocarbons, which are used for anesthesia , tri- and tetracyclic antidepressants and the also antidepressant MAO inhibitors increase when taken with the combination component reproterol the adverse effects on the heart such as increasing the heart rate or the risk of cardiac arrhythmias.


The combination of reproterol and cromolyn sodium should not be used if it is hypersensitive to any of the two active substances or if certain forms of allergic-type pneumonia are present. 

In the case of diseases that lead to reduced resilience of the heart, the combination should only be used after consultation with the attending physician. Which includes:

  • hypertrophic obstructive cardiomyopathy. Here, the heart muscle increases in size, without its performance increases accordingly
  • Cardiac arrhythmias with rapid heartbeat (tachyarrhythmia)
  • Performance limitations of the heart after a heart attack
  • severe narrowing of the coronary arteries (Herzenge, angina pectoris ).

The concomitant use of the drug combination with cardiac glycosides or diuretics should only be carried out under regular medical supervision. 

Hormonal imbalances due to severe hyperthyroidism or overproduction of catecholamines (such as an adrenal gland tumor) may only be treated with reproterol and cromoglycic acid after careful consideration of the benefit and risk by the attending physician. The same applies to patients with poorly adjusted diabetes (diabetes mellitus) or kidney and liver dysfunction.

Pregnancy and Lactation

The combination component reproterol can enter the blood of the unborn child through the placenta and cause damage there. Therefore, the active ingredient should be used during pregnancy only after consultation with the attending physician. It must be observed shortly before birth, the anti-inflammatory effect of reproterol.

Reproterol enters the breast milk and thus the baby. In order to avoid damage to the child, it should be weaned before treatment with the active substance.

What should be considered in children?

Infants and young children should not use reproterol and cromolyn sodium. Older children should inhale the combination only under adult supervision.


  • Impairment when driving or operating heavy machinery possible.
  • Reactivity may be impaired.
  • If the symptoms worsen, a doctor must be consulted.
  • The drug is one of the prohibited substances in the doping list.
  • If, despite the treatment, there is no satisfactory improvement or even a worsening of the symptoms, a doctor must be consulted.

Medicines can cause allergic reactions. Signs of this may include: redness, runny nose, itching, mucosal swelling, itching and redness of the eyes, constriction of the respiratory tract (asthma). In rare cases allergic shock with unconsciousness may occur. 

If you notice signs of an allergic reaction, inform a doctor immediately.

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